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KMID : 0352720140380030167
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Journal of Ginseng Research
2014 Volume.38 No. 3 p.167 ~ p.172
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Effects of Korean Red Ginseng (Panax ginseng), urushiol (Rhus vernicifera Stokes), and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) on the gut-liver axis of alcoholic liver disease
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Bang Chang-Seok
Hong So-Hyung
Suk Ki-Tae
Kim Jin-Bong
Han Sang-Hak
Sung Ho-Taik
Kim Eun-Ji
Kim Myoung-Jo
Kim Moon-Young
Baik Soon-Koo
Kim Dong-Joon
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Abstract
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Background: Roles of immune reaction and toll-like receptor-4 (TLR-4) have widely been established in the pathogenesis of alcoholic liver disease (ALD). Methods: We evaluated the biologic efficacy of Korean Red Ginseng (KRG), urushiol, and probiotics (Lactobacillus rhamnosus R0011 and Lactobacillus acidophilus R0052) in mouse models of ALD. Sixty C57BL/6 mice were equally divided into six feeding groups for 10 weeks: normal diet, alcohol, control, alcohol + KRG, alcohol + urushiol, and alcohol + probiotics. Alcohol was administered via a LiebereDeCarli liquid diet containing 10% alcohol. TLR-4 expression, proinflammatory cytokines, and histology, as well as the results of liver function tests were evaluated and compared. Results: No between-group differences were observed with regard to liver function. TLR-4 levels were significantly lower in the KRG, urushiol, and probiotics groups than in the alcohol group
(0.37±0.06ng/mL, 0.39±0.12ng/mL, and0.33±0.07ng/mL, respectively, vs. 0.88±0.31ng/mL; p < 0.05). Interleukin-1β levels in liver tissues were decreased among the probiotics and KRG groups. The tumor necrosis factor-α level of liver tissue was decreased in the KRG group. Conclusion: The pathological findings showed that alcohol-induced steatosis was significantly reduced by KRG and urushiol. As these agents improve immunologic capacity, they may be considered in potential anti-ALD treatments.
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KEYWORD
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alcoholic liver disease, Lactobacillus, Panax ginseng, urushiol
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